Whether you’re a seasoned PrizePicks player or brand new to the platform, having a smart strategy is essential for maximizing your entries. Our PrizePicks Week 2 NFL cheat sheet breaks down the top player props, highlights the best opportunities on the board, and helps you avoid common mistakes. With so many matchups to kick off the season, this guide will put you in the best position to make confident picks right from the start.
PrizePicks Building Blocks for NFL Week 2
🏈 100% Anytime TD Streaks This Week
- Chuba Hubbard: Anytime TD – 2 of last 2 games
- Derrick Henry: Anytime TD – 5 of last 5 games
- Josh Jacobs: Anytime TD – 10 of last 10 games
- Jalen Hurts: Anytime TD – 4 of last 4 games
- Bijan Robinson: Anytime TD – 4 of last 4 games
- Bucky Irving: Anytime TD – 3 of last 3 games
- Deebo Samuel: Anytime TD – 3 of last 3 games
- James Cook: Anytime TD – 2 of last 2 games
- De’Von Achane: Anytime TD – 2 of last 2 games
- Alvin Kamara: Anytime TD – 2 of last 2 games
- Marvin Harrison Jr.: Anytime TD – 2 of last 2 games
PrizePicks NFL Week 2 Line Movement
| Player | Team | Opp | Date & Time | Market | Previous Line | PrizePicks | Change | % Change |
| Aaron Rodgers | PIT | SEA | Sun Sep 14 11:00 am | Passing Yards | 223.5 | 233.5 | 10 | 4.5% |
| Lamar Jackson | BAL | CLE | Sun Sep 14 11:00 am | Passing Yards | 205.5 | 215.5 | 10 | 4.9% |
| Sam Darnold | SEA | @PIT | Sun Sep 14 11:00 am | Passing + Rushing Yards | 206.5 | 215.5 | 9 | 4.4% |
| Drake Maye | NE | @MIA | Sun Sep 14 11:00 am | Passing + Rushing Yards | 240.5 | 249.5 | 9 | 3.7% |
| Tua Tagovailoa | MIA | NE | Sun Sep 14 11:00 am | Passing Yards | 226.5 | 234.5 | 8 | 3.5% |
| Joe Flacco | CLE | @BAL | Sun Sep 14 11:00 am | Passing Yards | 235.5 | 242.5 | 7 | 3.0% |
| Derrick Henry | BAL | CLE | Sun Sep 14 11:00 am | Rushing + Receiving Yards | 97.5 | 104.5 | 7 | 7.2% |
| Caleb Williams | CHI | @DET | Sun Sep 14 11:00 am | Passing Yards | 213.5 | 219.5 | 6 | 2.8% |
| Russell Wilson | NYG | @DAL | Sun Sep 14 11:00 am | Passing Yards | 209.5 | 215.5 | 6 | 2.9% |
| J.K. Dobbins | DEN | @IND | Sun Sep 14 2:05 pm | Rushing Yards | 45.5 | 50.5 | 5 | 11.0% |
| Omarion Hampton | LAC | @LV | Mon Sep 15 8:00 pm | Rushing Yards | 53.5 | 57.5 | 4 | 7.5% |
| Stefon Diggs | NE | @MIA | Sun Sep 14 11:00 am | Receiving Yards | 38.5 | 42.5 | 4 | 10.4% |
| Dak Prescott | DAL | NYG | Sun Sep 14 11:00 am | Passing Yards | 245.5 | 249.5 | 4 | 1.6% |
| Baker Mayfield | TB | @HOU | Mon Sep 15 5:00 pm | Passing Yards | 229.5 | 233.5 | 4 | 1.7% |
| Josh Allen | BUF | @NYJ | Sun Sep 14 11:00 am | Passing + Rushing Yards | 266.5 | 270.5 | 4 | 1.5% |
| Josh Downs | IND | DEN | Sun Sep 14 2:05 pm | Receiving Yards | 34.5 | 38.5 | 4 | 11.6% |
| Caleb Williams | CHI | @DET | Sun Sep 14 11:00 am | Passing + Rushing Yards | 247.5 | 251.5 | 4 | 1.6% |
| De’Von Achane | MIA | NE | Sun Sep 14 11:00 am | Rushing Yards | 55.5 | 59.5 | 4 | 7.2% |
| Sterling Shepard | TB | @HOU | Mon Sep 15 5:00 pm | Receiving Yards | 19.5 | 22.5 | 3 | 15.4% |
This Week’s Top NFL Player Trends (Week 2)
🏈 NFL Week 2 – 100% Trends
🔥 Versus Opponent
- D.J. Moore: 50+ Rec Yds – 4/4 vs DET
- J. Waddle: 40+ Rec Yds – 4/4 vs NE
- H. Henry: 25+ Rec Yds – 4/4 vs MIA
- M. Andrews: 30+ Rec Yds – 4/4 vs CLE
- D. Njoku: 4+ Receptions – 3/3 vs BAL
- J. Gibbs: 50+ Rush Yds – 3/3 vs CHI
- G. Wilson: 50+ Rec Yds – 2/2 vs BUF
- J. Cook: 50+ Rush Yds – 2/2 vs NYJ
- M. Nabers: 60+ Rec Yds – 2/2 vs DAL
- D. Smith: 40+ Rec Yds – 2/2 vs KC
- B. Robinson: 50+ Rush Yds – 2/2 vs MIN
- P. Mahomes: 20+ Rush Yds – 2/2 vs PHI
💨 QB Alternate Lines
- J. Goff: 225+ Pass Yds – 7/7
- T. Lawrence: 5+ Rush Yds – 6/6
- L. Jackson: 30+ Rush Yds – 5/5
- J. Flacco: 200+ Pass Yds – 4/4
- P. Mahomes: 20+ Rush Yds – 3/3
- J. Allen: 200+ Pass Yds – 2/2
- A. Rodgers: 225+ Pass Yds – 2/2
- J. Hurts: 30+ Rush Yds – 2/2
- J. Burrow: 225+ Pass Yds – 10/11
- S. Darnold: 175+ Pass Yds – 18/20
Mahomes Free Winner vs. Eagles – NFL Week 2 on Sleeper!
Key Tips for Building Your Entries
- Understand Game Scripts
Consider how games are likely to play out. Will it be a high-scoring shootout or a defensive slugfest? Game scripts influence player performance, so align your picks with expected outcomes. - Look for Consistent Performers
Focus on players who have consistently hit their projected stats this season. This reduces risk and provides a reliable foundation for your picks. - Use Recent Player Trends
Analyze the last few weeks of data. Is a quarterback heating up? Is a running back facing a favorable defensive matchup? Tracking trends can help you spot value in player projections. - Diversify Your Picks
Avoid putting all your eggs in one basket. Spread your picks across multiple games and player types (passing, rushing, receiving, etc.) to mitigate risk. - Leverage Injury Reports
Late-breaking injury news can dramatically alter player projections. If a star player is ruled out, their backup often becomes a strong value play.
Common Mistakes to Avoid
- Overloading on Stars: Big names don’t always meet projections, especially against tough defenses.
- Ignoring Weather: Rain, snow, or high winds can heavily impact passing and kicking props.
- Chasing Big Cards: Stick to manageable entries like 2 or 3 player for a higher chance of success.