No. 3 – Peyton Manning

For the first time in his 18-year career, the Broncos quarterback will be missing a start during the middle of a season. Other than 2011, when he sat out the entire year after four neck surgeries, Manning has been on the field for every game of his illustrious career. But this week, the Broncos have sat him down, wanting him to heal his various ailments. That puts Manning in an uncomfortable spot. For one thing, his every move will be watched, as people evaluate whether or not he’s a good teammate by how much he helps out his understudy, Brock Osweiler. But also, and perhaps most importantly, it puts No. 18 in a spot where he may never get back on the field. If Osweiler plays well, Denver may decide to stick with their quarterback of the future. So throughout the game, Manning will be squirming; his future in the Mile High City hangs in the balance.